Immune Response to Viral Infection

Virus infection leads to a number of changes in infected cells. Interferon-alpha and -beta are produced, inhibiting viral replication in neighboring cells.

Antibodies block attachment and cause virus aggregation

Viral particles are processed and presented in class I MHC molecules for recognition by CD8+ cells, leading to CTL-mediated apoptosis.

Some viruses lead to downregulation of MHC I, leading to killing by NK cells.